Operation
• Resistance: high to medium
• Consistent performance (Delivered Dose, Fine Particle Dose) over wide range of airflow (30-90 L/min), storage conditions, orientations, etc.
Technical Characteristics
• Multi Single-Dose DPIs
• Made of 5 plastic components
• Dimensions:
7.5cm height, 6cm length, 3cm width
• Can be easily held in the palm
• Shape and dimensions can be custom-made
• Comprised of three parts (Fig. 1):
- mouthpiece with cover (1)
- supporting surface for the dose containing strip (2)
- storage compartment (3)
• Device storage capacity: 60 doses of medication
Medication Doses
• Each dose of medication is packed as a powder, in a specially designed strip made of
alu - alu (single-dose blister strip)
• Depending on the pharmaceutical product, the strip contains one (Fig. 2a) or two
(Fig. 2b) blisters, each filled with medication in powdered form
Formopen® strip: one blister, filled with formoterol + lactose
Fluticapen® strip: one blister, filled with fluticasone + lactose
Rolenium® strip: two blisters, one blister is filled with fluticasone + lactose,
the other with salmeterol + lactose.
The two active ingredients are NOT co-formulated anticipating thus, any potential patent complications.
Supporting Surface for Blister Strip
• The supporting surface (Fig. 3, Fig. 4) is designed to securely attach the single dose
blister strip
• For this purpose it contains:
- an attachment point (2a)
- one or two cavities (2b), depending on the product
- two strip guides (2c)
Formopen® device: one cavity
Fluticapen® device: one cavity
Rolenium® device: two cavities
APIs and Excipients
• APIs include: formoterol, fluticasone, budesonide, tiotropium and selected combinations
• Excipient used: lactose monohydrate inhalation grade
• Weight in blister: depending on the product 12 - 15 mg